Buy 5-MeO-DMT Online
WHAT IS 5-MEO-DMT?
5-MeO-DMT is short for 5-methoxy-N,N-dimethyltryptamine. It is found in many plant species and the venom of at least one toad—the Colorado River toad (_Incilius alvarius_)—which inhabits the Sonoran desert that lies between the Southern US and Northern Mexico.
5-MeO-DMT belongs to the tryptamine class. Tryptamines are similar in structure to tryptophan (the precursor to serotonin), and act as non-selective serotonin receptor agonists. Furthermore, they are serotonin-norepinephrine-dopamine releasing agents (SNDRA), which means tryptamines like 5-MeO-DMT are able to catalyse the release of serotonin, epinephrine, and dopamine. This action ultimately corresponds to major changes in sensory perception, mood, and thought pattern.
Unlike the better-known and more sought-after DMT, there is no suggestion of 5-MeO-DMT existing naturally in the human body.
5-MeO-DMT is one of the most potent psychedelics you can consume, and the experience can be intense and powerful—in both positive and negative ways. Though everyone will undergo a unique and individual experience, there are some general things you can expect.
What to Expect
Vaporizing or smoking 5-MeO-DMT powder is the most common route of administration. The effects are usually felt within the first 30 seconds after consumption, peaking from 1-15 minutes and lasting for up to half an hour. When taking synthetic 5-MeO-DMT, a threshold dose is around 1-2 mg, while a moderate-to-strong dose is 5-10 mg. When naturally derived, the threshold dose is 5-10 mg and a moderate-to-strong dose is 20-40 mg.
When swallowed, doses are generally higher, but also show generally unreliable results. Other less common routes of administration include sublingual (under the tongue) and injection.
The effects of 5-MeO-DMT come on strong, often with a loss of physical coordination and control. Users experience bright colors, moving environments, or recursive patterns, and perhaps even “environmental orbism” at higher doses. However, visual effects are limited. Unlike DMT, 5-MeO-DMT isn’t known for its visionary properties. The experience is more often described as a “perspective shift” characterized by physical, emotional, and conceptual effects.
One of the most common features of the 5-MeO-DMT experience is the enhancement of tactile awareness, which can reach the point of sensory overload. The body may also feel heavier. Intense emotions are typical, ranging from extreme fear to euphoria. During the onset, anxiety or excitement are often felt. It’s also common to experience an overwhelming sense of oneness with the universe, or a sense of being outside of time and space while simultaneously experiencing the totality of both. Ego death is also typical of the 5-MeO-DMT experience. Other effects include auditory hallucinations, time distortion, nausea, and memory loss.
Like the other tryptamines, 5-MeO-DMT has the same basic structure as DMT, but has a methoxy group in the R5 position. It works primarily as a serotonin (5-HT) receptor agonist, with a particular binding affinity to the 5-HT1A receptor subtype. It also binds to 5-HT2A and trace amine receptors, possibly mediating hallucinogenic effects via the latter. Reuptake inhibition of neurotransmitters such as noradrenaline and dopamine are also thought to be involved in 5-MeO-DMT’s function.
There is some evidence that indolealkylamines, including 5-MeO-DMT, cause serotonin syndrome when overdosed or combined. Of particular concern are possible interactions with monoamine oxidase inhibitors (MAOIs) such as harmaline or harmine. These are sometimes combined with the drug to enhance its effect, but can dangerously increase exposure to both 5-MeO-DMT and its active metabolite bufotenine.
Some other safety concerns have been flagged by animal studies. In rats, 5-MeO-DMT was found to induce hypothermia at low doses (0.5-1 mg/kg) and hyperthermia at high doses (3-10 mg/kg). In sheep, grazing on the 5-MeO-DMT-containing Phalaris tuberose/aquatica (or bulbous canary-grass) caused fatal tachycardia and respiratory failure. Although more likely due to other toxins in the plant, this severe reaction underscores the need for caution when approaching 5-MeO-DMT’s many and varied natural sources.
5-MeO-DMT doses are different depending on whether the substance is synthetic and naturally derived.
Small: 3-6 mg
Medium: 6-10 mg
Large: 11-15+ mg
Small: 10-20 mg
Medium: 20-40 mg
Large: 40-60+ mg